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Personalized Medicine
Personalized Medicine

A fundamental shift in drug development strategies is taking place. Before pharmaceutical companies focused on a small portfolio of "blockbuster" products based on large epidemiological studies. Nowadays, the trend is towards creating a host of more targeted therapies with higher efficacy in smaller patient groups.

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CAVΛDIS™ business strategy

This move to personalized medicine is fully in line with CAVΛDIS™ business strategy to generate a strong portfolio of cardiovascular biomarkers to be used as risk stratification tool for developing molecular diagnostics and as surrogate marker of efficacy in clinical trials. This approach is especially required in the field of atherosclerosis, since progression of the disease is slow and hard clinical endpoint studies requiring large patient numbers are extremely expensive for pharmaceutical companies. On average a "blockbuster" drug costs $1 billion to develop over a period of up to 12 years. To increase technical success rate and to reduce drug development time and costs, CAVΛDIS™ biomarkers may be used as surrogate endpoint in clinical trials.

Companion diagnostics

Personalized medicine is all about the individual, making use of distinct differences between patients and treatment responses. The ability to identify the right patient, provide the right therapy and obtain a consistent good clinical outcome is our ultimate goal. CAVΛDIS™ clinical biomarkers can be applied to target the "positive responders" for new and existing drug treatments. Biomarker can subsequently be used as companion diagnostics and are expected to play an increasingly important role in reimbursement policies.